Buy Levetiracetam (Keppra) online
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Indications and usage:
Keppra (Levetiracetam) tablets and oral solution are indicated for the treatment of partial-onset seizures in patients 1 month of age and older.
This medication is prescribed for adjunctive therapy for the treatment of:
Dosage and administration:
Partial-onset seizures (monotherapy or adjunctive therapy)
Myoclonic seizures in adults and pediatric patients 12 years and older
Primary generalized tonic-clonic seizures
Adult patients with impaired renal function
Dosage forms and strengt:
Overdosage:
Signs, symptoms and laboratory findings of acute overdosage in humans
The highest known dose of Keppra received in the clinical development program was 6000 mg/day. Other than drowsiness, there were no adverse reactions in the few known cases of overdose in clinical trials. Cases of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression and coma were observed with levetiracetam overdoses in postmarketing use.
Management of overdose
There is no specific antidote for overdose with Levetiracetam (Keppra). If indicated, elimination of unabsorbed drug should be attempted by emesis or gastric lavage; usual precautions should be observed to maintain airway. General supportive care of the patient is indicated including monitoring of vital signs and observation of the patient's clinical status. A Certified Poison Control Center should be contacted for up to date information on the management of overdose with Keppra.
Hemodialysis
Standard hemodialysis procedures result in significant clearance of levetiracetam (approximately 50% in 4 hours) and should be considered in cases of overdose. Although hemodialysis has not been performed in the few known cases of overdose, it may be indicated by the patient's clinical state or in patients with significant renal impairment.
Contraindications:
Known hypersensitivity to levetiracetam; angioedema and anaphylaxis have occurred.
Warnings and precautions:
Adverse reactions, side effects:
Most common adverse reactions of levetiracetam (incidence >= 5% more than placebo) include:
To report suspected side effects of Keppra (Levetiracetam) tablets, injections, and oral solution contact UCB pharmaceutical company or your local FDA.
Drug interactions:
Potential pharmacokinetic interactions of or with levetiracetam were assessed in clinical pharmacokinetic studies (phenytoin, valproate, warfarin, digoxin, oral contraceptive, probenecid) and through pharmacokinetic screening in the placebo-controlled clinical studies in epilepsy patients.
Related medications:
Use in specific populations:
Pregnancy
Plasma levels of levetiracetam may be decreased and therefore need to be monitored closely during pregnancy. Based on animal data, may cause fetal harm.
Lactation
Levetiracetam is excreted in human milk. There are no data on the effects of Keppra on the breastfed infant, or the effects on milk production.
The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Keppra and any potential adverse effects on the breastfed infant from this drug or from the underlying maternal condition.
Pediatric use
The safety and effectiveness of Levetiracetam (Keppra) for the treatment of partial-onset seizures in patients 1 month to 16 years of age have been established. The dosing recommendation in these pediatric patients varies according to age group and is weight-based.
Patient counseling information:
Psychiatric reactions and changes in behavior
Advise patients that Keppra (Levetiracetam) may cause changes in behavior (e.g. aggression, agitation, anger, anxiety, apathy, depression, hostility, and irritability) and psychotic symptoms.
Suicidal behavior and ideation
Counsel patients, their caregivers, and/or families that antiepileptic drugs (AEDs), including Keppra, may increase the risk of suicidal thoughts and behavior and advise patients to be alert for the emergence or worsening of symptoms of depression; unusual changes in mood or behavior; or suicidal thoughts, behavior, or thoughts about self-harm. Advise patients, their caregivers, and/or families to immediately report behaviors of concern to a healthcare provider.
Effects on driving or operating machinery
Inform patients that levetiracetam may cause dizziness and somnolence. Inform patients not to drive or operate machinery until they have gained sufficient experience on Keppra to gauge whether it adversely affects their ability to drive or operate machinery.
Anaphylaxis and angioedema
Advise patients to discontinue Keppra and seek medical care if they develop signs and symptoms of anaphylaxis or angioedema.
Dermatological adverse reactions
Advise patients that serious dermatological adverse reactions have occurred in patients treated with Levetiracetam (Keppra) and instruct them to call their physician immediately if a rash develops.
Withdrawal of Keppra
Advise patients and caregivers not to discontinue use of this medication without consulting with their healthcare provider. Keppra (Levetiracetam) should normally be gradually withdrawn to reduce the potential of increased seizure frequency and status epilepticus.
Pregnancy
Advise patients to notify their healthcare provider if they become pregnant or intend to become pregnant during Keppra therapy. Encourage patients to enroll in the North American Antiepileptic Drug (NAAED) pregnancy registry if they become pregnant.
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Here is a list of popular medications containing levetiracetam as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
| Trade name of the drug | Pharmaceutical forms and doses | Companies |
| Keppra | ||
| Keppra-XR | ||
| Levepsy | ||
| Levesam | ||
| Levetiracetam | ||
| Levetiracetam | ||
| Levipil | ||
| Torleva |
